名字：Berthold Hocher
照片：
職稱：教授
職務(wù)：教師
專業(yè)：病理學(xué)與病理生理學(xué)
聯(lián)系電話：
電子郵箱：Berthold.Hocher@medma.uni-heidelberg.de
實驗室主頁（可選）：
傳真（可選）：
通訊地址：bwin必贏
簡介：
Berthold Hocher，德國籍，教授?，F(xiàn)為bwin必贏“外專百人計劃”講座教授，德國海德堡大學(xué)曼海姆bwin必贏腎病內(nèi)分泌與風(fēng)濕科教授。Hocher教授是國際上知名的心血管-腎病學(xué)研究專家，是歐洲最早從事健康與疾病的發(fā)育起源學(xué)說的研究專家之一。Hocher教授擔(dān)任Journal of Hypertension等雜志學(xué)術(shù)編委。至今已獲得德國自然科學(xué)研究基金5項， 歐洲研究基金1項，F(xiàn)ressenius研究基金4項，多項企業(yè)合作基金等資助，已獲得多項歐洲及美國專利，已發(fā)表SCI收錄的文章280篇，總IF:1039.2,總引用次數(shù)：5126，總H-指數(shù)：38。
社會（學(xué)術(shù)）兼職：
1.瑞士伯恩大學(xué)客座教授
2.德國柏林洪堡大學(xué)夏立特bwin必贏心血管研究中心/藥理學(xué)研究所（CCR）客座教授
3.勃林格殷格翰醫(yī)藥集團(tuán)顧問
4.荷蘭Wijchen公司顧問
5.歐洲高血壓與腎臟病等學(xué)會委員
6.德國國家科學(xué)基金等資助申請評審員
所獲獎勵（榮譽）：
由于HOCHER教授的卓越研究，特別是DPP4抑制劑在腎臟疾病的研究，獲得了勃林格殷格翰醫(yī)藥集團(tuán)的多個研究基金作為獎勵。
代表性學(xué)術(shù)論文：
Hocher B, Th?ne-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T,Neumayer HH, Bauer C, Schleuning WD, Theuring F. Endothelin-1 transgenic mice develop renal cysts, interstitial fibrosis and glomerulosclerosis but not hypertension.J Clin Invest 99; 1380-1389 (1997)
Hocher B, Slowinski T, Stolze T, Pleschka A, Neumayer HH, Halle H. Association of maternal G protein ?3 subunit 825T allele with low birthweight.Lancet, 355;1241-1242 (2000)
Fischereder M, Luckow M, Hocher B, Wüthrich RP, Rothenpieler U, Schneeberger H, Panzer U, Stahl R, Neumayer HH, Hauser IA, Budde K, Neumayer HH, Kr?mer BK, Land W, Schl?ndorff D. Prolongation of renal transplant survival in patients lacking a functional CC chemokine receptor 5 (CCR5). Lancet 357; 1758-1761 (2001)
Pfab T, Slowinski T, Godes M, Halle H, Priem F, Hocher B.Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth. Circulation. 114(16):1687-92 (2006)
Mitrovic V, Seferovic P, Dodic, D,KrotinM,NeskovicA,DicksteinK, Devoogd H, B?cker C, Ziegler D, Godes M, Najow R, Essers H, Verboom C,Hocher B. Cardio-Renal Effects of the A1 Adenosine Receptor Antagonist SLV320 in Patients with Heart Failure.Circulation: Heart Failure2(6):523-31 (2009)
Nair AV&,,Hocher B&,Verkaart S, van Zeeland F, Pfab T, Slowinski T, Chen YP, Schlingmann KP, Schaller A, Gallati S, Bindels RJ, Konrad M, Hoenderop JG.Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.Proc Natl Acad Sci U S A.(2012)&,equal contributing first authors
Horikoshi M, ………………, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW,Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, B?nnelykke K, Bisgaard H, Eriksson JG, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I, Freathy RM. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.Nat Genet.45(1):76-82. doi: 10.1038/ng.2477(2013)
Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenfuhrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S,Hocher B. The DPP4 inhibitorLinagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways innon-diabetic rats with 5/6 nephrectomy. Kidney Int, 2016 May;89(5):1049-61. doi: 10.1016/j.kint.2016.01.016.
Hocher B, Tsuprykov O.Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors.Nat Rev Nephrol. 2017 Dec;13(12):728-730.
Li J, Lu YP, Tsuprykov O, Hasan AA, Reichetzeder C, Tian M, Zhang XL, Zhang Q, Sun GY, Guo J, Gaballa MMS, Peng XN, Lin G, Hocher B.Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet.Diabetologia. 2018 Aug;61(8):1862-1876
專利（可選）：
1. NON-OXIDIZED,BIOLOGICAL ACTIVE PARATHYROID HORMONE DETERMINES MORTALITY IN，Country of Granting：USA，Owner：Franz Paul Armbruster, Berthold Hocher, Heinz Juergen Roth
2.Use of a dpp-4 inbitor in podocytes related disorders and/or nephrotic syndrome, Country of Granting：USA，Owner：Thomas Klein, Maximilian von EYNATTEN, Berthold Hocher, Michael Mark, Yuliya SHARKOVSKA, Less
3.Means and methods of measuring parathyroidhormone in patients suffering, Country of Granting：EU，Owner：Franz Paul Armbruster, Berthold Hocher, Hans Juergen Groen, Heinz Juergen Roth
4.MEANS AND METHODS OF MEASURING PARATHYROID HORMONE IN PATIENTS SUFFERING FROM OXIDATIVE STRESS, Country of Granting：USA，Owner：Franz Paul Armbruster, Berthold Hocher, Hans Juergen Groen, Heinz Juergen Roth
