名字：李濤

照片：

職稱：副教授

專業(yè)：免疫學(xué)學(xué)位點，再生醫(yī)學(xué)和損傷修復(fù)

電子郵箱：63665116@qq.com

通訊地址：bwin必贏免疫學(xué)教研室

簡介：

受教育經(jīng)歷

2002.9-2008.7，北京大學(xué)，醫(yī)學(xué)部基礎(chǔ)bwin必贏生物化學(xué)與分子生物學(xué)系，碩博連讀，獲理學(xué)博士學(xué)位

1997.9-2002.7，北京大學(xué)，醫(yī)學(xué)部基礎(chǔ)bwin必贏，基礎(chǔ)醫(yī)學(xué)專業(yè)本科，獲醫(yī)學(xué)學(xué)士學(xué)位

研究工作經(jīng)歷

2017.2-至今，湖南師范大學(xué)，bwin必贏檢驗系，副教授

2012.9-2017.2，浙江師范大學(xué)，化學(xué)與生命科學(xué)學(xué)院，副教授

2008.7-2012.9，浙江師范大學(xué)，化學(xué)與生命科學(xué)學(xué)院，講師

主持或參加科研項目（課題）及人才計劃項目情況

1.國家自然科學(xué)基金面上項目，81870201，干細胞心肌程序分化中HDAC1、EZH2的階段特異性效應(yīng)及其成因，2019.01-2022.12，57萬，主持

2.國家自然科學(xué)基金面上項目，31470082，發(fā)育期心臟感應(yīng)環(huán)境脅迫的Nkx2.5蛋白剪切機制研究，2015.01-2016.12，30萬，主持

3.國家自然科學(xué)基金青年基金，31101057，心肌程序分化過程中MSK、RSK激酶階段特異性效應(yīng)及機制的研究，2012.01-2014.12，25萬，主持

代表性學(xué)術(shù)論文：

1.Li T, He Z, Zhang X, Tian M, Jiang K, Cheng G, Wang Y. The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation. Cell Signal. 2019 Feb;54:17-26.

2.Li T, Zhang X, Jiang K, Liu J, Liu Z. Dural effects of oxidative stress on cardiomyogenesis via Gata4 transcription and protein ubiquitination. Cell Death Dis. 2018 Feb 14;9(2):246.

3.Chen Y, Huang Q, Zhou H, Wang Y, Hu X, Li T. Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. Oncotarget.2016 Aug 2;7(31):50401-50416.

4.Yu Z, Li T, Wang C, Deng S, Zhang B, Huo X, Zhang B, Wang X, Zhong Y, Ma X. Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells. Oncotarget.2016 Mar 29;7(13):15725-37.

5.Li P, Sun X, Ma Z, Liu Y, Jin Y, Ge R, Hao L, Ma Y, Han S, Sun H, Zhang M, Li R, Li T, Shen L. Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs. INT J BIOL SCI . 2016 Feb 20;12(5):505-17.

6.Liu Y, Li P, Liu K, He Q, Han S, Sun X, Li T, Shen L. Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells. PLOS ONE.2014 Oct 14; 9(10):e109588. DOI: 10.1371/journal.pone.0109588

7.Liu Z, Li T, Jiang K, Huang Q, Chen Y, Qian F. Induction of Chemoresistance by All-Trans Retinoic Acid via a Noncanonical Signaling in Multiple Myeloma Cells. PLOS ONE. 2014 Jan 9;9(1):e85571 DOI: 10.1371/journal.pone.0085571

8.Li T, Liu Z, Jiang K, Ruan Q. Angiopoietin2 Enhances Doxorubin Resistance in HepG2 cells by Upregulating Survivin and Ref-1 via MSK1 activation.Cancer Lett. 2013, 337(2):276-84.

9.Li T, Liu Z, Hu X, Ma K, Zhou C. Involvement of ERK-RSK cascade in phenylephrine-induced phosphorylation of GATA4.Biochim Biophys Acta - Molecular Cell Research. 2012, 1823(2):582-92.

10.Hu X, Li T, Zhang C, Liu Y, Xu M, Wang W, Jia Z, Ma K, Zhang Y, Zhou C. GATA4 regulates ANF expression synergistically with Sp1 in a cardiac hypertrophy model. J Cell Mol Med.2011 Sep;15(9):1865-77.

11.Liu Z, Li T, Liu Y, Jia Z, Li Y, Zhang C, Chen P, Ma K, Affara N, Zhou C. WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim Biophys Acta - Molecular Cell Research. 2009,1793(2):300-11.

12.Li T, Li Y, Jia Z, Chen P, Ma K, Zhou C. Carboxyl terminus of Nkx2.5 impairs its interaction with p300. J Mol Biol.2007, 370(5):976-992.